Peptide C105Y( —— )

Catalog No. M30180 CAS No. 247572-63-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Peptide C105Y
Note

Research use only, not for human use.
Brief Description

C105Y, a synthetic peptide (CSIPPEVKFNKPFVYLI) based on the amino acid sequence corresponding to residues 359-374 of alpha1-antitrypsin, enhances gene expression from DNA nanoparticles.
Description

C105Y, a synthetic peptide (CSIPPEVKFNKPFVYLI) based on the amino acid sequence corresponding to residues 359-374 of alpha1-antitrypsin, enhances gene expression from DNA nanoparticles.
In Vitro

When human hepatoma cells (HuH7) were incubated with fluorescently labeled C105Y for as little as 3 min, C105Y displays nuclear and cytoplasmic staining with enrichment of fluorescent signal in the nucleus and nucleolus. C105Y peptide is routed to the nucleolus very rapidly in an energy-dependent fashion, whereas membrane translocation and nuclear localization are energy-independent. When tested the involvement of known endocytosis pathways in uptake and trafficking of this peptide, C105Y peptide is internalized by a clathrin- and caveolin-independent pathway, although lipid raft-mediated endocytosis may play a role in peptide intracellular trafficking.
In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

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Research Area

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Indication

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CAS Number

247572-63-0
Formula Weight

1994.4
Molecular Formula

C97H148N20O23S
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

Sequence:{Cys}{Ser}{Ile}{Pro}{Pro}{Glu}{Val}{Lys}{Phe}{Asn}{Lys}{Pro}{Phe}{Val}{Tyr}{Leu}{Ile}

Rhee M, et al. Mechanism of uptake of C105Y, a novel cell-penetrating peptide. J Biol Chem. 2006 Jan 13;281(2):1233-40.

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