Peptide C105Y

Research use only, not for human use.

C105Y, a synthetic peptide (CSIPPEVKFNKPFVYLI) based on the amino acid sequence corresponding to residues 359-374 of alpha1-antitrypsin, enhances gene expression from DNA nanoparticles.

C105Y, a synthetic peptide (CSIPPEVKFNKPFVYLI) based on the amino acid sequence corresponding to residues 359-374 of alpha1-antitrypsin, enhances gene expression from DNA nanoparticles.

When human hepatoma cells (HuH7) were incubated with fluorescently labeled C105Y for as little as 3 min, C105Y displays nuclear and cytoplasmic staining with enrichment of fluorescent signal in the nucleus and nucleolus. C105Y peptide is routed to the nucleolus very rapidly in an energy-dependent fashion, whereas membrane translocation and nuclear localization are energy-independent. When tested the involvement of known endocytosis pathways in uptake and trafficking of this peptide, C105Y peptide is internalized by a clathrin- and caveolin-independent pathway, although lipid raft-mediated endocytosis may play a role in peptide intracellular trafficking.

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Others

Other Targets

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247572-63-0

1994.4

C97H148N20O23S

>98% (HPLC)

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Sequence:{Cys}{Ser}{Ile}{Pro}{Pro}{Glu}{Val}{Lys}{Phe}{Asn}{Lys}{Pro}{Phe}{Val}{Tyr}{Leu}{Ile}

(-20℃)

With Ice Pack

≥ 2 years